John Florveus pulled down 10 rebounds to help the Bulldogs (6-7) overcome a season-high 25 turnovers.
Kevin Larsen scored 14 points to lead George Washington (6-7). The Colonials went 0-for-12 on 3-point attempts, missing all but two of them in the second half.
George Washington shot a season-worst 24.6 percent from the field.
The Bulldogs were just 4-for-11 on free-throw attempts before Caldwell-Pope and Djurisic combined to hit Georgia’s last six.
Caldwell-Pope has scored Georgia’s team high in all but one game this season
Forward Brandon Morris had a turnover on Georgia’s first possession, setting a trend in which the Bulldogs committed 11 miscues in the first 14 minutes.
Caldwell-Pope’s 3 at the 3:49 mark ended an 11-2 run by the Colonials and got Georgia within one of the lead.
Georgia, which had won three straight over Mercer, Southern Cal and Florida A&M, began the game ranked No. 297 in offense, but scored nearly nine points under its average.
The Colonials, who were outscored 34-20 in the second half, began the game ranked No. 207 with a 62.5 scoring average
Vincent Williams replaced Charles Mann at point guard in the starting lineup for Georgia.
Georgia opens its Southeastern Conference schedule Wednesday at No. 13 Florida. The Colonials will host St. Bonaventure in their first Atlantic 10 game Wednesday.
The Bulldogs and Colonials were playing for the first time. Their only common opponent this season, Youngstown State, beat both teams in November.